La coinfezione con l’epatite C HCV nelle persone HIV+ si associa ad una maggiore prevalenza di patologie cardiovascolari. E’ questo il risultato dello studio cross-sectional di Matthew Freiberg e dei suoi collaboratori dell’ Università di Pittsburgh pubblicato sulla rivista AIDS (2007,21,193).
La coinfezione con l’epatite C HCV nelle persone HIV+ si associa ad una maggiore prevalenza di patologie cardiovascolari. E’ questo il risultato dello studio cross-sectional di Matthew Freiberg e dei suoi collaboratori dell’ Università di Pittsburgh pubblicato sulla rivista AIDS (2007,21,193).Freiberg e i suoi collaboratori hanno analizzato le caratteristiche cliniche e di laboratorio di 399 pazienti HIV+, di cui il 50.1% affetti da coinfezione HCV.
La prevalenza della patologia cardiovascolare è risultata maggiore nei pazienti con confezione HCV+ che in quelli con sola infezione da HIV (11.1 versus 2.5%). Dopo aggiustamento dei dati per età, il rischio di patologia cardiovascolare è risultato maggiore nei pazienti con confezione HCV/HIV (odds ratio: 4.65; 95% IC 1.70-12.71). La relazione tra epatite C e patologia cardiovascolare si è mantenuta anche dopo aggiustamento dei dati secondo le caratteristiche sociodemografiche, l’uso di droghe, e i fattori di rischio cardiovascolare.
Secondo gli autori dello studio, questi dati suggeriscono che l’epatite C può essere associata ad un maggiore rischio di patologie vascolari nei pazienti con confezione HIV/HCV.
Articolo originale:
Hepatitis C Linked to Higher Cardiovascular Risk in Coinfected Patients
By Liz Highleyman
Due to the aging of the population and the metabolic side effects of certain antiretroviral drugs, cardiovascular disease is a growing concern for people with HIV. Those who also have hepatitis C may be at even greater risk.
As reported in the January 11, 2007 issue of AIDS, researchers conducted a study to examine the association between hepatitis C and prevalent cardiovascular disease among HIV-infected individuals. This cross-sectional analysis included data from 395 HIV positive participants in the HIV Longitudinal Interrelationships of Viruses and Ethanol (HIV-LIVE) cohort, a prospective cohort of HIV positive individuals with current or past alcohol problems; half the participants (50.1%) were coinfected with hepatitis C virus (HCV).
The investigators analyzed health questionnaires and laboratory data using logistic regression analysis to estimate the odds ratio for the prevalence of cardiovascular disease among HIV-HCV coinfected individuals compared to those with HIV alone.
Results
– The prevalence of cardiovascular disease was higher among HIV-HCV coinfected participants compared to those with HIV alone (11.1% vs 2.5%, respectively).
– After adjusting for age, the odds ratio for the prevalence of cardiovascular disease was significantly higher among coinfected patients (adjusted OR 4.65; 95% CI 1.70-12.71).
– The relationship between HCV and cardiovascular disease persisted after adjusting for age and other sociodemographic characteristics, substance use, and cardiovascular risk factors in separate regression models.
Conclusion
“Coinfection with hepatitis C among a cohort of HIV-infected individuals was associated with a higher age-adjusted odds for the prevalence of cardiovascular disease,” the authors concluded. “These data suggest that hepatitis C infection may be associated with an increased risk of cardiovascular disease among those coinfected with HIV.”
University of Pittsburgh School of Medicine, Pittsburgh, PA; University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA; Boston Medical Center and Boston University School of Medicine, Boston, MA; Boston University School of Public Health.
1/16/07
Reference
M Freiberg, D M Cheng, K L Kraemer, and others. The association between hepatitis C infection and prevalent cardiovascular disease among HIV-infected individuals. AIDS 21(2): 193-197. January 11, 2007.
Fonte:Aidsmap
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